Hyperplastic arteriolosclerosis and Fibrinoid Necrosis

[Gdl88]

I am a bit confused about how these two findings are linked with malignant hypertention. Pathoma says that HA can lead to Fibrinoid necrosis whilst RR describes these two as indipendent conditions. How HA can lead to FN?

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[solitarius]

HA & fibrinoid necrosis are two independent outcomes from malignant HTN. HA is the vessel's response to higher pressure as a protective mechanism, but fibrinoid necrosis is when the pressure overwhelms the vessel.

 

[Gdl88]

So Pathoma is wrong...... But in this case how the high pressure leads to fibrinoid necrosis?
fibrinoid necrosis is caused by a deposit of immunocomplexes in the wall of the arteries, so how hypertension can do that?

 

[seminoma]

So Pathoma is wrong...... But in this case how the high pressure leads to fibrinoid necrosis?
fibrinoid necrosis is caused by a deposit of immunocomplexes in the wall of the arteries, so how hypertension can do that?

Pathoma isn't wrong. HTN --> vessel damage --> protein leak --> fibrinoid necrosis.