Everyone, I have read many posts about loans and medical school and the way I explain it to people is, I feel (although very biased), a very practical way to think about it. This is somewhat lengthy but bear with me. The student I had talked to had a full ride at the #11 ranked school vs. full price at the #7 school (using US News ONLY to show that they are basically in the same tier). Now he felt that he liked the #7 school better, like the city better, etc. The final price difference was about ~125K over the four years. Original amount: 125K Now add the total interest: 25-30K (over ~25yrs) Total: 155k Now . . . 52 weeks per year x 4 years = 208 Now to put that amount of money in perspective, this student could go on a $1,000 vacation EVERY OTHER WEEKEND FOR ALL FOUR YEARS OF MEDICAL SCHOOL and still have >$50,000 in the bank <img border="0" alt="[Wowie]" title="" src="graemlins/wowie.gif" /> Heck, he could study really hard the first year and go on a $1,000 trip EVERY SINGLE weekend for the last three years. Even if your situation is not as drastic, do the math and see how much better the cheaper medical school looks now. Even if the other school has a much better reputation, this is a tough pill to swallow. I know you can't really borrow the money to go on the vacations, but you and your family can spend that money when you finish. Imagine you and your significant other enjoying yourselves on a $1,000 vacation even once a month (or drive a Ferrari, no seriously, you can lease a Ferrari for ~$1200 a month) and still save money. Disclaimer: I know that these numbers may be slightly off, but you get the point.