Aug 13, 2013
9
0
Status
Pre-Medical
...Inhibition of the GTPase activity of Gs.....Is this referring to Gs G protein leading to cAMP and PKA ?

It is from the NBME exam, none of the answers seem to fit , can anyone help?
 

AZ7

2+ Year Member
Jan 4, 2015
126
59
Status
Medical Student
Yes.
After binding to activating ligand extracellularly, the alpha subunit of G protein replaces its GDP with GTP. Later GTPase converts it back to GDP. Inhibition of GTPase can lead to persistent activity.
 
OP
P
Aug 13, 2013
9
0
Status
Pre-Medical
Yes.
After binding to activating ligand extracellularly, the alpha subunit of G protein replaces its GDP with GTP. Later GTPase converts it back to GDP. Inhibition of GTPase can lead to persistent activity.
Thanks !
 
OP
P
Aug 13, 2013
9
0
Status
Pre-Medical
Hi

Can you help me wth this one :

18-year-old M with acute lymphoblastic leukemia with 3-day hx of fever & left0sided chest pain. Taking chemo asparaginase, disorubicin, prednisone, and vincristine. ANC less than 500. T 39.2. Lower lobe infiltrate and a moderate pleural effusion on the left. Photomicrograph of a periodic acid-Schiff stain of pleural fluid obtained via thoracentesis is shown. Appropriate Rx?
 
OP
P
Aug 13, 2013
9
0
Status
Pre-Medical
Hi

Can you help me wth this one :

18-year-old M with acute lymphoblastic leukemia with 3-day hx of fever & left0sided chest pain. Taking chemo asparaginase, disorubicin, prednisone, and vincristine. ANC less than 500. T 39.2. Lower lobe infiltrate and a moderate pleural effusion on the left. Photomicrograph of a periodic acid-Schiff stain of pleural fluid obtained via thoracentesis is shown. Appropriate Rx?
Maybe picture of Cryptococcus, then Amp B is good.