...Inhibition of the GTPase activity of Gs

[Peanut01]

...Inhibition of the GTPase activity of Gs.....Is this referring to Gs G protein leading to cAMP and PKA ?

It is from the NBME exam, none of the answers seem to fit , can anyone help?

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[AZ7]

Yes.
After binding to activating ligand extracellularly, the alpha subunit of G protein replaces its GDP with GTP. Later GTPase converts it back to GDP. Inhibition of GTPase can lead to persistent activity.

 

[Peanut01]

Yes.
After binding to activating ligand extracellularly, the alpha subunit of G protein replaces its GDP with GTP. Later GTPase converts it back to GDP. Inhibition of GTPase can lead to persistent activity.

Thanks !

 

[Peanut01]

Hi

Can you help me wth this one :

18-year-old M with acute lymphoblastic leukemia with 3-day hx of fever & left0sided chest pain. Taking chemo asparaginase, disorubicin, prednisone, and vincristine. ANC less than 500. T 39.2. Lower lobe infiltrate and a moderate pleural effusion on the left. Photomicrograph of a periodic acid-Schiff stain of pleural fluid obtained via thoracentesis is shown. Appropriate Rx?

 

[Peanut01]

Hi

Can you help me wth this one :

18-year-old M with acute lymphoblastic leukemia with 3-day hx of fever & left0sided chest pain. Taking chemo asparaginase, disorubicin, prednisone, and vincristine. ANC less than 500. T 39.2. Lower lobe infiltrate and a moderate pleural effusion on the left. Photomicrograph of a periodic acid-Schiff stain of pleural fluid obtained via thoracentesis is shown. Appropriate Rx?

Maybe picture of Cryptococcus, then Amp B is good.

 

[Peanut01]

No Candida