Hi Everyone,
I must agree with the advice given in the previous posts. I had my interview at UHS last month, and it went quite smoothly. And, while I wouldn't call it laid-back, I wouldn't call it intimidating either. Both of my interviewers acted very professionally and respectfully. I think it helped that I am a former Marine and one of my interviewers was in the Navy
And, it is always a good sign when they take you into their confidence half way through the interview and feel comfortable enough to use a profanity or two to describe some bureaucratic aspect of the school they do not like
I will stress again the importance of not only knowing your reasons for choosing medicine and osteopathy, but also being able to articulate them concisely. I found it very helpful to say them aloud to myself.
As for being honest and being yourself, I cannot do anything but agree completely with what others have written. It worked wonders for me - I applied with a 3.0 cumulative GPA (but I am in a post-bacc program, too) and was asked about it, as expected. I did not BS at all, and told them straight up that when I started college I had no interest in academics whatsoever, and had no idea what I wanted to do with my life; that I had about a dozen W's on my transcript because I lost interest in classes half way through and dropped out; that I had F's on all my classes for one semester because I finally lost interest in school altogether, and dropped out. In short, I covered my application's weakness with as much clarity and honesty as I could muster. And, guess what! - that was the end of it. They did not even raise the issue again during the interview. Also, I think it is important not to exaggerate your experiences, accomplishments etc. Present everything for what it is worth, but have something significant to say about what you got out of your experiences. They are intelligent people and can see right through the fluff.
Good luck in your pursuits!