Can you guys help me out on this discrepency please: According to Rapid Review path by goljan, in intravascular hemolysis since the amount of hemoglobin bound to haptoglobin is so small the unconjugated bilirubin is not significantly increased. (page 215) And I see no reason why the conjugated bilirubin should be increased since there is no obstruction in the liver or bile ducts and the liver should be functioning normally. So then according to Goljan there should be no jaundice in patients with intravascular hemolysis. However in reality in diseases with intravascular hemolysis such as G6PD deficiency there is juandice "Jaundice and splenomegaly may be present during a crisis." http://www.emedicine.com/med/topic900.htm Also my hemotology professor confirmed that there is jaundice in intravascular hemolysis. So is Goljan wrong when he said that unconjugated bilirubin is not significantly increased, or am I missing something?? thanks in advance.