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I am working on a question that is really bothering me...
I won't post the exact question since it's probably against some copyright law, but it deals with a hypothetical gene. According to the answer key, the gene in question looks like this:
3'---start codon---(5' untranslated region)---1st intron---1st exon---etc.---5'
I don't know why they think that the 1st intron comes before the 1st exon. Everything I have seen shows it the other way around. The question is really convoluted, but it boils down to "What is downstream of the 1st exon?" I thought it was the 5' untranslated region, but they say it's the 1st intron. Also up for debate is my understanding of the term "downstream." Even though DNA is read 3' to 5', upstream and downstream should be based on how it is synthesized 5' to 3', so downstream is toward the 3' end (and closer to the start codon of the gene).
What do you guys think (besides the obvious that this question is just crap)?
I won't post the exact question since it's probably against some copyright law, but it deals with a hypothetical gene. According to the answer key, the gene in question looks like this:
3'---start codon---(5' untranslated region)---1st intron---1st exon---etc.---5'
I don't know why they think that the 1st intron comes before the 1st exon. Everything I have seen shows it the other way around. The question is really convoluted, but it boils down to "What is downstream of the 1st exon?" I thought it was the 5' untranslated region, but they say it's the 1st intron. Also up for debate is my understanding of the term "downstream." Even though DNA is read 3' to 5', upstream and downstream should be based on how it is synthesized 5' to 3', so downstream is toward the 3' end (and closer to the start codon of the gene).
What do you guys think (besides the obvious that this question is just crap)?