Is a lipid anchored protein an integral or peripheral protein?

Discussion in 'DAT Discussions' started by panmit, May 16, 2014.

  1. SDN is made possible through member donations, sponsorships, and our volunteers. Learn about SDN's nonprofit mission.
  1. panmit

    panmit 2+ Year Member

    Joined:
    May 14, 2014
    Messages:
    256
    Status:
    Pre-Dental
    Is a lipid anchored protein an integral or peripheral protein?

    I think it is a integral protein because it is covalently linked inside the membrane. What do you guys think?
     
  2. SDN Members don't see this ad. About the ads.
  3. DogeDDS

    DogeDDS Wow 2+ Year Member

    Joined:
    Mar 8, 2014
    Messages:
    210
    Status:
    Pre-Dental
    Edit. Nevermind
     
    Last edited: May 16, 2014
  4. Daneosaurus

    Daneosaurus D2 2+ Year Member

    Joined:
    Mar 13, 2012
    Messages:
    1,840
    Status:
    Dental Student
    It's neither. They are their own class: lipid-anchored proteins. Integral proteins extend through both of the bilayers, peripheral proteins attach on either side of the bilayer, lipid-anchored covalently attach to either the N-terminus of the internal lipid structure or to the cysteine residues.
     
  5. panmit

    panmit 2+ Year Member

    Joined:
    May 14, 2014
    Messages:
    256
    Status:
    Pre-Dental
    transmembrane proteins extend through both bilayers. Its a type of integral protein. Integral proteins do not necessarily have to extend through both layers
     
  6. BrazilianRider

    BrazilianRider 2+ Year Member

    Joined:
    Oct 28, 2013
    Messages:
    755
    Status:
    Pre-Dental
    Panmit is right. I took a Eukaryotic Cell Structure course over the past semester and everything except Protein-Bound Proteins are basically Integral Proteins.

    If it's a protein bound to an Integral Membrane Protein, then it is Peripheral.

    Remember that you only need salts or a pH change to isolate Peripherals, but you need detergent to isolate Integrals.
     

About the ads

Share This Page