Is gabapentin and/or lyrica safe in pregnancy and/or breastfeeding patients?

[Blitz2006]

Reviewing the literature online, seems to be somewhat limited in recommendations:

Gabapentin and breastfeeding: a case report - PubMed

The aim of this study was to describe the milk-plasma ratio and relative infant dose of gabapentin in a breastfeeding mother and to determine the well-being of her exposed infant. The mother-infant pair was studied over a 24-hour dose interval at steady state. Gabapentin concentrations were...

www.ncbi.nlm.nih.gov

Adverse pregnancy outcomes in women exposed to gabapentin and pregabalin: data from a population-based study | Journal of Neurology, Neurosurgery & Psychiatry

Your thoughts SDN?

And if safe, up to normal max doses (3600 mg/300 mg)?

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[Ducttape]

at this point in time, esp with more data suggesting questionable evidence, I would not start.

 

[Ferrismonk]

Gabapentin and Lyrica are both secreted in breast milk.

These medications suppress nerve function, not a great thing for growing nervous systems.

They're both considered a category C.

Some evidence out there of damaged babies.

I say no.

 

[BobBarker]

Do not recommend for the developing brain.

 

[deleted131481]

Agree with the above. In pregnancy - adverse effects seen for gabapentin animal studies. We will never have anything beyond retrospective data. Regarding lactation and medications, this is a good resource for most drugs:

Drugs and Lactation Database (LactMed®) - NCBI Bookshelf

Rarely do I find stopping gabapentinoids for a year will significantly decrease quality of life.

 

[SommeRiver]

Nope