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Kerbs Cycle and Glycolysis

Discussion in 'Pre-Medical - MD' started by 34140, Apr 25, 2004.

  1. 34140

    34140 Senior Member
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    I am studying for Bio Chem :eek: and can't get the hang of the Kerbs cycle or glycolisis, Does any one know any mnuemonics for them? Any help would be appreciated!
     
  2. TheRussian

    TheRussian Life Size Mirror
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    The best way to learn this is to understand what the starting product is and what the final product is and understanding how to push electrons in order to get from one intermidiate to the other. This way you'll learn this and anytime you need to a certain intermidiate you'll be able to figure it out with reasonable ease.

    Sorry if this is not what you were looking for but understanding the strategies to use as well as how to push electrons will get you a lot farther then memorization. Plus you'll be able to apply the same techniques to other cycles like the urea cycle as well as the fatty acid biosynthesis and breakdown.
     
  3. 34140

    34140 Senior Member
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    Thanks! That might just work!
     
  4. BubbleBobble

    BubbleBobble Where's the "any" key?
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    Draw out all the steps on a big piece of paper. It really does help.
     
  5. BioMedResearch

    BioMedResearch Senior Member
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    Isn't it the KREBS not kerbs cycle?
     
  6. hilikus

    hilikus Senior Member
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    pyruvic acid...yeah, that's the ticket!
     
  7. flighterdoc

    flighterdoc Rocket Scientist
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    THAT might be part of his problem.... :laugh:
     
  8. TheRussian

    TheRussian Life Size Mirror
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    Yes it is but we are forgiving of such spelling mistakes on this forum. Right guys?
     
  9. I'm actually making a large metabolism chart right now. I am using all kinds of different colored pencils. It is not fun and there are arrows everywhere.
     
  10. cad_15

    cad_15 Senior Member
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    draw the entire cycle on your board and stare at it, when you are tired stare at it and if you get sick of staring at it...just stare at it more. It always works for me.
     
  11. flighterdoc

    flighterdoc Rocket Scientist
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    Yeah, I have several books with the chart from hell, and if i was the engineer responsible, Id be in trouble :laugh:
     
  12. Paws

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    I second the stare at it philosophy, as well as the write it out 10,00 x.

    The more I could make the connections and the more I poured over the book, the better I understood the infinite, awesome beauty that it biochem ...

    With these cycles, think of what exactly is happening at each step - here the oxaloacetate is combining with the acetyl coa, which comes from pyruvate; and then other really important things like: succinate is donating its electrons to FAD which then gives them to Complex II, in the electron TC, etc. These will help you on the exam.

    When I study I write out what I am reading as I go along. I keep a stack of lined paper by the side of my book and just keep writing things out that seem important. This helps me alot with chemistry stuff and really gnarly physics things. :luck:


    I'm not really sure what this little flower thing means, but I thought it was cute ...
     
  13. 34140

    34140 Senior Member
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    I meant KREBS!!!!!!!!!!!!!!!!!!! See how behind I am,.....

    Thanks to all with real suggestions!
     
  14. dentate_gyrus

    dentate_gyrus Member
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    Does any one know any mnuemonics for them?
    Here is one for Krebs I have heard before:
    Can
    I
    Keep
    Selling
    Sex
    For
    Money
    Officer?

    Citrate
    Isocitrate
    alpha-ketoglutarate
    succinyl cholate
    succinate
    fumarate
    maloate
    oxaloacetate.

    Excuse my spelling on the species, it has been a while. I found this provided a framework to hang details upon. Some intermediates not listed are very important as well.
     
  15. idq1i

    Physician 15+ Year Member

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    O ur Oxaloac
    C ity citrate
    I s isocitrate
    K ept alpha kg
    S afe succinyl - coA
    A nd coA
    S ound succinate
    F rom Fumarate
    M alice malate
     
  16. CH3CH2OH

    CH3CH2OH born to be wild-type
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    The Sound of Glucose
    ------------------------------

    Aldehyde sugars are always aldoses and
    If there's a ketone we call them ketoses
    For linear molecules Fischer's the thing
    Glucose can do some incredible things

    Onto the glucose we add a 'P' to it
    ATP energy ought to renew it
    Quick rearranging creates F6P
    Without requiring input energy

    At a high rate
    Add a phosphate
    With PFK
    F1,6BP is made up this way
    So we can run and play

    Aldolase breaks it and then it releases
    DHAP and a few G3Pieces
    These both turn in to 1,3 BPG
    Adding electrons onto NAD

    Phosphate plus ADP makes ATP
    While giving cells what they need - en-er-gy
    Making triphosphate's a situa-shun
    Of substrate level phosphoryla-shun

    3-B-P-G
    2-B-P-G
    Lose a water
    PEP gets a high energy state
    Just to make py-ru-vate

    So all the glucose gets broken and bent
    If there's no oxygen cells must ferment
    Pyruvate / lactate our cells hit the wall
    Some lucky yeast get to make ethanol

    This is the end of your glucose's song
    Unless you goof up and get it all wrong
    Break it, don't make it to yield ATP
    You'll save your cells from fu-til-i-ty
    -----------------------------------------------

    want more? click here :D
     
  17. martianMIKE

    martianMIKE Junior Member
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    Cindy
    Is
    Kinky
    So
    She
    Fornicates
    More
    Often
     
  18. NubianPrincess

    NubianPrincess Perpetually Bored
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    That song is toooo cute :)
     
  19. 34140

    34140 Senior Member
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    Thanks ! :laugh:
     

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