I just finished my 1st year at DMU and I have 4 children. My husband is a pastor, so his schedule allows him some flexibility. It has been difficult, but certainly not impossible. I think time-managment is the key.
Truly, having a family has helped me keep my priorities straight! I want to do my best academically (and I'm doing fine), but my family always comes first.
Also, my children are somewhat older (15, 14, 12, and 8) so they are more independent and can help out around the house a little bit. They also understand Mom's need to study. So I can't really say what it's like having LITTLE children in med school. But I can say this last year was difficult, but do-able, even with children.