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Kinase, Phosphorylase, and Phosphatase?

Discussion in 'MCAT Study Question Q&A' started by m25, Sep 20, 2014.

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  1. m25

    m25

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    May 28, 2014
    So my understanding is that:
    Kinase and Phosphorylase always add phosphate group to a substrate
    Phosphatase always removes phosphate group from a substrate

    Is this correct? And what is the difference between Kinase and Phosphorylase?
     
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  3. Cawolf

    Cawolf 2+ Year Member

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    Feb 26, 2013
    A kinase transfers a phosphate group from a high energy compound such as ATP - so these reactions generally consume an ATP.

    A phosphorylase catalyzes the adding of a inorganic phosphate group to a compound.

    An example of a kinase is phosphofructokinase which takes fructose-6-phosphate to fructose-1,6-phosphate and uses an ATP (that donates the phosphate group). These are what we see in glycolysis.
     
  4. StIGMA

    StIGMA Doctor Professor 7+ Year Member

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    PhD
    "Phosphorylase" refers specifically to an enzyme that catalyzes the phosphorolytic removal of a non-reducing terminal glucose residue of a glucan. Eg: uses inorganic phosphate to "cleave" a closed-chain (non-reduced) glucose off of a glucose chain.

    Otherwise, enzymes that remove phosphates are generally termed phosphatases.
     
    Last edited: Sep 20, 2014

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