1. Visit this thread to beta-test StudySchedule.org. StudySchedule is a free nonprofit site that builds dynamic MCAT study schedules unique for your needs and timeline.
Hey, Guest, do you know how much will it cost you to apply to medical school? Check out SDN's Medical School Application Cost Calculator and plan your budget.

Kinase, Phosphorylase, and Phosphatase?

Discussion in 'MCAT Study Question Q&A' started by m25, Sep 20, 2014.

  1. SDN is made possible through member donations, sponsorships, and our volunteers. Learn about SDN's nonprofit mission.
  1. m25

    m25

    304
    19
    May 28, 2014
    So my understanding is that:
    Kinase and Phosphorylase always add phosphate group to a substrate
    Phosphatase always removes phosphate group from a substrate

    Is this correct? And what is the difference between Kinase and Phosphorylase?
     
  2. SDN Members don't see this ad. About the ads.
  3. Cawolf

    Cawolf 2+ Year Member

    3,342
    2,050
    Feb 26, 2013
    A kinase transfers a phosphate group from a high energy compound such as ATP - so these reactions generally consume an ATP.

    A phosphorylase catalyzes the adding of a inorganic phosphate group to a compound.

    An example of a kinase is phosphofructokinase which takes fructose-6-phosphate to fructose-1,6-phosphate and uses an ATP (that donates the phosphate group). These are what we see in glycolysis.
     
  4. StIGMA

    StIGMA Doctor Professor 7+ Year Member

    1,016
    150
    Jul 6, 2008
    PhD
    "Phosphorylase" refers specifically to an enzyme that catalyzes the phosphorolytic removal of a non-reducing terminal glucose residue of a glucan. Eg: uses inorganic phosphate to "cleave" a closed-chain (non-reduced) glucose off of a glucose chain.

    Otherwise, enzymes that remove phosphates are generally termed phosphatases.
     
    Last edited: Sep 20, 2014

Share This Page