MudPhud20XX Full Member 10+ Year Member Joined Nov 26, 2013 Messages 1,349 Reaction score 193 Jun 17, 2015 #1 So FA says loop diuretics abolish hypertonicity of medulla and prevent concentration of urine. Can anyone explain the mech? Many thanks in advance. Members don't see this ad.
So FA says loop diuretics abolish hypertonicity of medulla and prevent concentration of urine. Can anyone explain the mech? Many thanks in advance. Members don't see this ad.
S seminoma Full Member 7+ Year Member Joined Aug 9, 2014 Messages 1,976 Reaction score 1,029 Jun 17, 2015 #2 Block NKCC reabsorption = no solutes in the medulla. No solutes in the medulla = no gradient for reabsorption of water. Upvote 0 Downvote
Block NKCC reabsorption = no solutes in the medulla. No solutes in the medulla = no gradient for reabsorption of water.