ateria radicularis magna

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Hey,

Is anyone prescribing these or have any thoughts on them?

Basically, I want to know if there is actually a decreased risk of CV/renal/GI morbidity. And if so, is the decreased risk decreased enough to use them?

Thank you!
 

lobelsteve

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Hey,

Is anyone prescribing these or have any thoughts on them?

Basically, I want to know if there is actually a decreased risk of CV/renal/GI morbidity. And if so, is the decreased risk decreased enough to use them?

Thank you!
Yup, breaking those generics in half doednt work.
 

lobelsteve

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Rarely do i rx any nsaids. My patients are usually over 60 with too much risk for nsaids.
 

willabeast

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i really like ground up turmeric root. 1/2 teaspoon a day.
Amazon product
 

lobelsteve

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ateria radicularis magna

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I have never been exposed to Limbrel before in any context...

makes me wonder what other stuff people are prescribing.

I prescribe butterburr for migraines.
 

willabeast

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Is there good evidence for this? My mother-in-law swears by it...but also thinks that IV aloe vera is a viable treatment for cancer.
"good evidence" for a generic ground up root like turmeric will never appear, because the world wide profits from turmeric sales would never pay for a good study, OTOH, negative results would create big pharma profits and keep them from going belly up. i can tell you this - i got great results in my clinic, and according to a nephrologist i asked, turmeric does not negatively impact renal function. big win :)
 

bedrock

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Turmeric can help some people.

Better yet to just get curcumin, which is the actual anti-inflammatory component of tumeric.
 

willabeast

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Turmeric can help some people.

Better yet to just get curcumin, which is the actual anti-inflammatory component of tumeric.
are you saying curcumin is cheaper than turmeric? where do you buy it? how much do you pay?
 

lobelsteve

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How about you say turmeric might help you, but medically speaking it is not supported. But no downside.
 

willabeast

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How about you say turmeric might help you, but medically speaking it is not supported. But no downside.
have fun!
http://umm.edu/health/medical/altmed/herb/turmeric
Precautions
The use of herbs is a time-honored approach to strengthening the body and treating disease. However, herbs can trigger side effects and may interact with other herbs, supplements, or medications. For these reasons, you should take herbs with care, under the supervision of a health care provider.

Turmeric in food is considered safe.

Turmeric and curcumin supplements are considered safe when taken at the recommended doses. However, taking large amounts of turmeric for long periods of time may cause stomach upset and, in extreme cases, ulcers. People who have gallstones or obstruction of the bile passages should talk to their doctor before taking turmeric.

If you have diabetes, talk to your doctor before taking turmeric supplements. Turmeric may lower blood sugar levels. When combined with medications for diabetes, turmeric could cause hypoglycemia (low blood sugar).

Although it is safe to eat foods with turmeric, pregnant and breastfeeding women should not take turmeric supplements.

Because turmeric may act like a blood thinner, you should stop taking it at least 2 weeks before surgery. Tell your doctor and surgeon that you have been taking turmeric.

Possible Interactions
If you are being treated with any of the following medications, you should not use turmeric or curcumin in medicinal forms without first talking to your health care provider.

Blood-thinning medications -- Turmeric may strengthen the effects of these drugs, raising the risk of bleeding. Blood thinners include warfarin (Coumadin), clopidogrel (Plavix), and aspirin, among others.

Drugs that reduce stomach acid -- Turmeric may interfere with the action of these drugs, increasing the production of stomach acid:

  • Cimetidine (Tagamet)
  • Famotidine (Pepcid)
  • Ranitidine (Zantac)
  • Esomeprazole (Nexium)
  • Omeprazole (Prilosec)
  • Lansoprazole (Prevacid)
Diabetes Medications -- Turmeric may strengthen the effects of these drugs, increasing the risk of hypoglycemia (low blood sugar).

Supporting Research
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Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol. 2007;595:1-75.

Asai A, Miyazawa T. Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue. J Nutr. 2001;131:2932-2935.

Asher GN, Spelman K. Clinical utility of curcumin extract. Altern Ther Health Med.2013;19:20-2.

Baum L, et al. Curcumin effects on blood lipid profile in a 6-month human study. Pharmacol Res. 2007;56:509-14.

Blumenthal M, Goldberg A, Brinckmann J. Herbal Medicine: Expanded Commission E Monographs. Newton, MA: Integrative Medicine Communications; 2000:379-384.

Bolognia: Dermatology, 3rd ed. Philadelphia, PA: Elsevier Saunders; 2012.

Curcuma longa (turmeric). Monograph. Altern Med Rev. 2001;6 Suppl:S62-S66.

Darvesh AS, Aggarwal BB, Bishayee A. Curcumin and Liver Cancer: A Review. Curr Pharm Biotechnol. 2011 Apr 5. [Epub ahead of print]

Davis JM, Murphy EA, Carmichael MD, Zielinski MR, Groschwitz CM, Brown AS, Ghaffar A, Mayer EP. Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage. Am J Physiol Regul Integr Comp Physiol. 2007 Mar 1 [Epub ahead of print]

Dorai T, Cao YC, Dorai B, Buttyan R, Katz AE. Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate. 2001;47:293-303.

Dorai T, Gehani N, Katz A. Therapeutic potential of curcumin in human prostate cancer. II. Curcumin inhibits tyrosine kinase activity of epidermal growth factor receptor and depletes the protein. Mol Urol. 2000;4:1-6.

Funk JL, Frye JB, Oyarzo JN, Kuscuoglu N, Wilson J, McCaffrey G, et al. Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis.Arthritis Rheum. 2006;54:3452-64.

Gautam SC, Gao X, Dulchavsky S. Immunodilation by curcumin. Adv Exp Med Biol.2007;595:321-41.

Gescher A J, Sharma R A, Steward W P. Cancer chemoprevention by dietary constituents: a tale of failure and promise. Lancet Oncol. 2001;2:371-379.

Goel A, Kunnumakkara AB, Aggarwal BB. Curcumin as "Curecumin": from kitchen to clinic.Biochem Pharmacol. 2008;75:787-809.

Hanai H, Iida T, Takeuchi K, Watanabe F, Maruyama Y, Andoh A, et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. 2006;4:1502-6.

Handler N, Jaeger W, Puschacher H, Leisser K, Erker T. Synthesis of novel curcumin analogues and their evaluation as selective cyclooxygenase-1 (COX-1) inhibitors. Chem Pharm Bull (Tokyo). 2007;55:64-71.

Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 2000;57:1221-1227.

Jagetia GC, Aggarwal BB. "Spicing up" of the immune system by curcumin. J Clin Immunol.2007;27:19-35.

Johnson JJ, Mukhtar H. Curcumin for chemoprevention of colon cancer. Cancer Lett. 2007 Apr 18; [Epub ahead of print]

Kapakos G, Youreva V, Srivastava AK. Cardiovascular protection by curcumin: molecular aspects. Indian J Biochem Biophys. 2012; 49:306-15.

Kim DS, Kim JY, Han Y. Curcuminoids in neurodegenerative diseases. Recent Pat CNS Drug Discov. 2012; 7:184-204.

Kim MS, Kang HJ, Moon A. Inhibition of invasion and induction of apoptosis by curcumin in H-ras-transformed MCF10A human breast epithelial cells. Arch Pharm Res. 2001;24:349-354.

Krishnaswamy K. Traditional Indian spices and their health significance. Asia Pac J Clin Nutr. 2008;17 Suppl 1:265-8.

Nagaraju GP, Aliya S, Zafar SF, Basha R, Diaz R, El-Rayes BF. The impact of curcumin on breast cancer. Integr Biol (Camb). 2012; 4:996-1007.

Pari L, Tewas D, Eckel J. Role of curcumin in health and disease. Arch Physiol Biochem.2008;114:127-49.

Phan TT, See P, Lee ST, Chan SY. Protective effects of curcumin against oxidative damage on skin cells in vitro: its implication for wound healing. J Trauma 2001;51:927-931.

Rakel D. Rakel: Integrative Medicine, 3rd ed. Philadelphia, PA: Elsevier Saunders; 2012.

Rao CV. Regulation of COX and LOX by curcumin. Adv Exp Med Biol. 2007;595:213-26.

Sharma RA, Ireson CR, Verschoyle RD. Effects of dietary curcumin on glutathione S-Transferase and Malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels. Clin Cancer Res. 2001;7:1452-1458.

Sharma RA, Steward WP, Gescher AJ. Pharmacokinetics and pharmacodynamics of curcumin. Adv Exp Med Biol. 2007;595:453-70.

Shehzad A, Khan S, Shehzad O, Lee YS. Curcumin therapeutic promises and bioavailability in colorectal cancer. Drugs Today (Barc). 2010;46:523-32. Review.

Shehzad A, Lee J, Lee YS. Curcumin in various cancers. Biofactors. 2013; 39:56-68.

Shehzad A, Rehman G, Lee YS. Curcumin in inflammatory diseases. Biofactors. 2013; 39:69-77.

Shishodia S, Singh T, Chaturvedi MM. Modulation of transcription factors by curcumin. Adv Exp Med Biol. 2007;595:127-48.

Su CC, Lin JG, Li TM, Chung JG, Yang JS, Ip SW, et al. Curcumin-induced apoptosis of human colon cancer colo 205 cells through the production of ROS, Ca2+ and the activation of caspase-3. Anticancer Res. 2006;26:4379-89.

Suryanarayana P, Satyanarayana A, Balakrishna N, Kumar PU, Reddy GB. Effect of turmeric and curcumin on oxidative stress and antioxidant enzymes in streptozotocin-induced diabetic rat. Med Sci Monit. 2007;13:BR286-92.

White B, Judkins DZ. Clinical Inquiry. Does turmeric relieve inflammatory conditions? J Fam Pract. 2011;60:155-6. Review.

Zafir A, Banu N. Antioxidant potential of fluoxetine in comparison to Curcuma longa in restraint-stressed rats. Eur J Pharmacol. 2007;572:23-31.
 

ampaphb

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Your response would be much more useful if you only posted research relevant to the topics being discussed.
 

willabeast

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Your response would be much more useful if you only posted research relevant to the topics being discussed.
Agree. Too much work however.