I have no experience with Loyola, but I have interviewed at SLU twice, so I have a pretty good understanding of their school at this point.
First off- they're moving their curriculum towards 1.5 year pre-clinical system which many schools are moving towards. So you would take your Step 1's earlier, and have more time for elective clerkships before choosing residencies.
It's a Jesuit institution, so they're huge on working with the underserved, so if you're looking to get involved in that way, they have a lot of great opportunities for it. And Saint Louis has a very large underserved population, so the exposure to disease is going to be very broad.
The city of St. Louis itself has a small town yet urban feel. There's a lot of history and culture, food, huge craft beer scene, and occasional music festivals and concerts. It's also a big sports city, especially with the Rams and Cardinals. They also have a lot of parks and museums, and best of all, it is a very affordable city. There are some crime issues, but most students live in a college bubble of sorts, and commute with their car to SLU, so they don't really run into many problems.
The facilities itself are very nice, and I'm actually quite fond of the campus. They have a brand new research building, and their education building is also very new. Great simulation lab, and an entire standardized patient center with about 14 realistic examination rooms. On the other hand though, their hospital is nothing to write home about, and I've heard they're having a lot of financial concerns with it. It's kind of run down and cramped feeling, and US News doesn't rank them very high in many specialties. It'll get the job done though.
Overall, I think it's a great school with a lot of opportunities, and if I were you I would make the effort to go out there and see if it's right for you. The professors and students are phenomenal, and compared to many of the other school's I've interviewed at, seem to have the closest bond and connection.
I hope that was helpful.