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There are always going to be people who are just plain not nice, whether they are pre-meds, meds, or any other group of people. But the simple fact of the matter is that the stress of med school in particular can and does really alter one's personality. There have been a few times already (and I'm only a few months in) that I've noticed myself snapping at family or friends that aren't going through this because they expect more time from me than I have have. I'm sure you've all heard this before, and I don't really expect anyone to internalize before going through this process, but med school can really strain your relationships. When you do make it, always try to allocate specific blocks of time in your day to give a bit of time to those you care about. If you don't plan the time that way, you surely won't have it and that can make med school feel very isolated.
Wise advice, I think.