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- Mar 15, 2011
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For those who have taken Biochem (or Biology) before, here are the numbers for net ATP production for a molecule of d-glucose, from start to finish:
Glucose --> 2 Pyruvate = 2 ATP + 2 NADH
2 Pyruvate --> 2 Acetyl-CoA = 2 NADH
2 Acetyl-Coa through TCA --> 2 x (1 GTP, 1 FADH2, 3 NADH) = 2 GTP + 2 FADH2 + 6 NADH
That gives us: 4 ATP equivalents + 10 NADH + 2 FADH2
Oxidative P-lation:
10 NADH * 2.5 ATP/NADH = 25 ATP
2 FADH2 * 1.5 ATP/FADH2 = 3 ATP
+ 4 ATP equivalents from before = 25 + 3 + 4 = 32 net ATP
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Now, my question: sometimes, we take into account the ATP cost of moving the 2 NADH's from the cytosol (those produced in glycolysis) into the mito. matrix. That happens at a cost of, according to my records, 1 ATP per NADH...
Does that mean that our actual net production is only 30 ATP?
Additionally, are there cells that do not have to 'pay' to get NADH into the mito. matrix?
Are there cells that are 'better' at ATP production then others, that will get us more net ATP?
Glucose --> 2 Pyruvate = 2 ATP + 2 NADH
2 Pyruvate --> 2 Acetyl-CoA = 2 NADH
2 Acetyl-Coa through TCA --> 2 x (1 GTP, 1 FADH2, 3 NADH) = 2 GTP + 2 FADH2 + 6 NADH
That gives us: 4 ATP equivalents + 10 NADH + 2 FADH2
Oxidative P-lation:
10 NADH * 2.5 ATP/NADH = 25 ATP
2 FADH2 * 1.5 ATP/FADH2 = 3 ATP
+ 4 ATP equivalents from before = 25 + 3 + 4 = 32 net ATP
--------
Now, my question: sometimes, we take into account the ATP cost of moving the 2 NADH's from the cytosol (those produced in glycolysis) into the mito. matrix. That happens at a cost of, according to my records, 1 ATP per NADH...
Does that mean that our actual net production is only 30 ATP?
Additionally, are there cells that do not have to 'pay' to get NADH into the mito. matrix?
Are there cells that are 'better' at ATP production then others, that will get us more net ATP?