nuclear vs cytosolic hormone receptors

Discussion in 'Step I' started by hsans23, Jun 21, 2008.

  1. hsans23

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    does anyone know off the top of their head which receptors are nuclear vs which are cytosolic and move into the nucleus? dumb question but i am forgetting everything as my test comes up :scared:
     
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  3. docmd2010

    docmd2010 Senior Member
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    hsans what's up buddy

    thryoid hormoness have nuclear receptors. steroids have receptors located in the cytoplasm. once the steroid binds, dimerization may occur, the heat shock protein is released, and then this complex goes into the nucleus. the zinc finger goes and binds to the DNA
     
  4. LUBDUBB

    LUBDUBB Freakaholic
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    I agree. I think Vit A may also go directly to nucleus like thyroid.
     
  5. rox

    rox ossified
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    BRS physiology has a nice table demonstrating the different types of receptors for all hormones.
     
  6. 45408

    45408 aw buddy
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    It does, but if you want a really detailed one, HY Cell & Molecular has an extremely thorough one on page 19. I got a question right on the real deal because of that chart.
     
  7. hsans23

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    thx guys, brain fart panic moment - say a prayer for me tomorrow please :)
     
  8. GynGuy1983

    GynGuy1983 C&A Psychiatry Fellow
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    Remember also that steroid hormones don't need 2nd messengers and don't need cytoplasmic receptors ;)

    Just wanted to add that, as basic as that may be :p
     
  9. agranulocytosis

    Physician 10+ Year Member

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    I thought that what docmd2010 said was right on the money. It was my understanding that as a rule all steroid hormones have receptors in the cytoplasm except for thyroid hormones.
     

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