# of phosphate bonds undergoing hydrolysis during ATP-->AMP + PPi

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nickelbackfan

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I was under the impression that it was three (two from ATP to AMP) and one from the PPi. There is a question in BR bio, passage 12, chapter 8, question 78 asking about this. Can someone please clear this up? Thanks

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I was under the impression that it was three (two from ATP to AMP) and one from the PPi. There is a question in BR bio, passage 12, chapter 8, question 78 asking about this. Can someone please clear this up? Thanks

ATP consist of adenosine + 3 phosphate groups. When you cleave ATP => AMP + PPi, you cleave it only once to separate the adenosine monophosphate (AMP) from the inorganic pyrophosphate (PPi). There is no reason to cleave each phospate from ATP to get to AMP. At least, I don't recall off the top of my head.

There can be two high energy bonds if ATP => ADP + Pi => AMP + Pi, but it depends on the metabolic process. It isn't neccessary though.
 
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