Because that's where Drake is located, it will be difficult. You might have an easier time looking for jobs in Ames, Indianola, Newton, Boone, Winterset, Oskaloosa, etc. if you're living in or near Des Moines. I have heard that if you want to work in Marshalltown, in retail at least, you should be English/Spanish bilingual.
I grew up there, in case you hadn't figured it out, although I did not attend Drake.