PBr3/Pyridine, SOCl2/Pyridine with COOH

[JustwantDDS]

Could someone show how/what happens?

COOH+ SOCl2
or
COOH + PBr3

do they need to have pyrimidine w/them too?

Is the product just an acid chloride or bromide?

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[rmm30]

Could someone show how/what happens?

COOH+ SOCl2
or
COOH + PBr3

do they need to have pyrimidine w/them too?

Is the product just an acid chloride or bromide?

Yep. A couple things though. Pyrimidine is the single ringed, smaller class of nitrogenous base in a nucleotide. The catalyst you are thinking of is Pryridine. No you don't require it. You normally see pyridine when you are catalyzing a rxn in which you substitute the OH group of an alcohol with Cl, Br, or Tosylate using SOCl2, PBr3, and Tosyl Chloride respectively.

If you are confused about anything concerning carboxylic acid derivatives, you might want to check out Chads video on this. It is hands down the best coverage on this topic I've ever seen (as far as DAT goes). It blows Kaplan out of the water on this subject. Best part is it's set up as a really easy to understand flow chart. And once you learn it you will never forget it!

 

[flyingforever]

You will get acid halide + the leaving group.

Pyridine is not the requirement.

Here is the helpful link: http://pages.towson.edu/jdiscord/WWW/332_problem_sets/Chapter20_21/Review_Exam2.pdf

Please send me your Chad's website info