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PBr3/Pyridine, SOCl2/Pyridine with COOH

Discussion in 'DAT Discussions' started by JustwantDDS, Aug 2, 2011.

  1. JustwantDDS

    JustwantDDS DrAMG
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    Could someone show how/what happens?

    COOH+ SOCl2
    or
    COOH + PBr3

    do they need to have pyrimidine w/them too?

    Is the product just an acid chloride or bromide?
     
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  3. rmm30

    2+ Year Member

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    Yep. A couple things though. Pyrimidine is the single ringed, smaller class of nitrogenous base in a nucleotide. The catalyst you are thinking of is Pryridine. No you don't require it. You normally see pyridine when you are catalyzing a rxn in which you substitute the OH group of an alcohol with Cl, Br, or Tosylate using SOCl2, PBr3, and Tosyl Chloride respectively.

    If you are confused about anything concerning carboxylic acid derivatives, you might want to check out Chads video on this. It is hands down the best coverage on this topic I've ever seen (as far as DAT goes). It blows Kaplan out of the water on this subject. Best part is it's set up as a really easy to understand flow chart. And once you learn it you will never forget it!
     
  4. flyingforever

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