PCOS and oligomenorrhea

[theTruth_97]

---

Members don't see this ad.

I would really appreciate it if someone could explain to me how PCOS leads to oligomenorrhea?

 

[Transposony]

Increased LH------> increased stimulation of the ovarian theca cells---------> increase the production of androgens (eg, testosterone, androstenedione)
Decreased FSH relative to LH--------> ovarian granulosa cells unable to aromatize androgens to estrogens------> decreased estrogen levels-----> anovulation.

 

[cbrons]

Continuing where transposony left off, the excess androgens get converted to estrone by aromatase in peripheral adipocytes and this provides constant (tonic) negative feedback on the HP axis which inhibits ovulation