There's probably an answer for this somewhere on here, but thought I would post anyway. Re-reading Pathoma and came across pernicious anemia. Dr. S states that it's actually T-cell mediated (i.e. Type IV hypersensitivity reaction), while First Aid has it listed as a Type II hypersensitivity reaction. Dr. S mentions that the antibodies are just a consequence of destruction (aka Hashimoto's). This sort of makes more sense to me, given that IF is usually intracellular anyway...so this seems like an unlikely target that would actually end up contributing to parietal cell destruction. So...is First Aid wrong?