Ploidy of Hypertrophic Cells

Discussion in 'Step I' started by BMW M3, Jun 3, 2008.

  1. BMW M3

    BMW M3 Senior Member
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    What is the ploidy of cardiac myocytes in concentric hypertrophy?
    A) 1N
    B) 2N
    C) 3N
    D) 4N


    According to Goljan, hypertrophic myocytes are 4N because the block is in G2. I did a literature search and couldn't find any articles that backed up what he said. Anyone have any insight into this?
     
  2. Mediculous

    Mediculous The Verbal Herman Munster
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    I don't get it from the get-go. I thought cell division happens in hyperplasia, not hypertrophy...
     
  3. agranulocytosis

    Physician 10+ Year Member

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    Additionally, I thought hypertrophy was due to increased levels of proteins and not simply replication of DNA. Maybe transcription and replication can occur simultaneously?
     
  4. peter90036

    peter90036 not out fishing
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    tangentially...
    deep thoughts: this step 1 is going to be a pain in the ass...
     
  5. SOUNDMAN

    SOUNDMAN Senior Member
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    I just listened to this lecture as well and thought it sounded fishy as well, but wasn't sure. I would assume either 2n or 4n, Goljan does say arrested in G2 therefore it's 4n, but it didn't make sense to me.

    However this source seems to support the claim of Goljan. See about 1/2 way down.

    http://www.reading.ac.uk/pharmacy/staff/brooks_g/
     
  6. R_C_Hutchinson

    R_C_Hutchinson Senior Member
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    I have a faint memory of reading through robbins and seeing ridiculous ploidy numbers for hypertrophic myocytes and a small discussion that this implied myocyte regeneration may be a pharmacologically possible goal (though for USMLE purposes myocytes are supposed to be permanent cells). I want to say they had numbers up to 8n, either way in a question like that I'd almost always pick the biggest answer.
     
  7. Monica Lewinsky

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    The more important question is whether or not they would expect us to know this on the big exam...
     

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