Not sure about other schools, but I know that Penn welcomes you to send in letters of rec at any time, even if your AMCAS app is not yet processed/transmitted.
My pre-med advisor said that he typically waits until the schools are in session before mailing out the committee letters - he's said that in the past, many letters get lost when he's mailed them over the summer vs. waiting till mid-August to early September.
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