http://www.review.com/Medical/templates/temp2.cfm?topic=Test&body=USMLE/index36.cfm&Link=USMLE.cfm&special=Medical.cfm Do I Need to Take the USMLE? Although you are required to sit for COMLEX if you are at an osteopathic medical school or graduate program, you may also want to take the USMLE. If you think that you will apply to graduate allopathic residencies in addition to osteopathic residencies, you will very likely need to sit for one or more Steps of USMLE. But as an osteopathic medical student or graduate, if you do not plan to transfer to an allopathic medical school or apply to allopathic residencies you do not necessarily need to sit for any Step of the USMLE. To be certain, you should contact the state medical board where you feel you may want to practice after you have completed your graduate training. No allopathic medical school or allopathic graduate training program requires its students or residents to sit for and pass any Level of COMLEX. In fact, allopathic programs will generally not accept COMLEX scores in place of USMLE scores for those purposes. The good news if you plan to sit for both COMLEX and USMLE is that each Level of COMLEX is offered within 1 week to 2 months of the associated Step of the USMLE. This makes preparing for either exam more useful obviously.