Jul 19, 2015
7
3
Status
Non-Student
Can anyone elaborate why a non-selective BB, classically propranolol, is the beta blocker of choice in performance anxiety and other anxiety disorders?

If the mechanism is via reduction of adrenergic activity resulting in slowing HR, reducing tremor, etc.. Shouldn't beta-1 selective BB's be just as effective? Where might blocking B2 receptors be helpful in this?

Has anyone had success using b1 selective drugs for generalized anxiety and performance anxiety? Also if you have some experience I'd be curious where you've found the dosing sweet spot to be..

Thanks!
 

Ironspy

10+ Year Member
Sep 29, 2008
131
216
Status
Resident [Any Field]
Can anyone elaborate why a non-selective BB, classically propranolol, is the beta blocker of choice in performance anxiety and other anxiety disorders?

If the mechanism is via reduction of adrenergic activity resulting in slowing HR, reducing tremor, etc.. Shouldn't beta-1 selective BB's be just as effective? Where might blocking B2 receptors be helpful in this?

Has anyone had success using b1 selective drugs for generalized anxiety and performance anxiety? Also if you have some experience I'd be curious where you've found the dosing sweet spot to be..

Thanks!
Propranolol is lipophilic and crosses the blood brain barrier readily is my understanding
 
About the Ads
OP
S
Jul 19, 2015
7
3
Status
Non-Student
Error -- see next post below!
 
Last edited:
OP
S
Jul 19, 2015
7
3
Status
Non-Student
Propranolol is lipophilic and crosses the blood brain barrier readily is my understanding
Good point, I've heard this before -- but what then is the proposed mechanism of action in reducing anxiety by crossing BBB?

Also are any b1 selective drugs lipophilic like propranolol?
 
Last edited:

clausewitz2

10+ Year Member
Oct 13, 2008
2,133
2,374
Status
Resident [Any Field]
Propranolol is lipophilic and crosses the blood brain barrier readily is my understanding
The mechanism is definitely central; older literature on this point compared propanolol (which crosses the BBB readily) and atenolol (which is far less lipophilic). Lo and behold you can have anxiety reduction with atenolol but it requires much higher equivalent doses than propanolol.
 

Stagg737

5+ Year Member
Jul 2, 2013
7,573
9,552
Decapod 10
Status
Resident [Any Field]
Good point, I've heard this before -- but what then is the proposed mechanism of action in reducing anxiety by crossing BBB?

Also are any b1 selective drugs lipophilic like propranolol?
Metoprolol is B1 selective and lipophilic, propranolol hits b1 and b2.
 
  • Like
Reactions: SCPA and Crayola227
About the Ads