Q. What is the reason for increased RBC count when 2 genes are deleted in alpha-thalassemia? Since thalassemia is a problem in globin chain synthesis, Hb can't be formed and thus anemia occurs. How is it possible that Hb is decreased but RBC count is increased ? I was thinking they hold the proportional relationship but here it's not so. Can anybody pls help to keep these things straight.Thanks.