SDN members see fewer ads and full resolution images. Join our non-profit community!

Question About Hydrolysis of ATP

Discussion in 'DAT Discussions' started by ojyarumaru, Aug 27, 2010.

  1. ojyarumaru

    ojyarumaru 7+ Year Member

    May 19, 2010
    When ATP is hydrolyzed to ADP + Pi, is this an endothermic/ exothermic reaction? Also, is it exergonic/ energonic? I saw a destroyer problem that stated that hydrolysis of ATP is exergonic. But breaking a bond requires energy, so would that mean ATP hydrolysis is endothermic AND exergonic??? Please help, thanks!
  2. SDN Members don't see this ad. About the ads.
  3. casper22


    Apr 13, 2010
    St Louis
    Thats true...
  4. loveoforganic

    loveoforganic -Account Deactivated- 2+ Year Member

    Jan 30, 2009
    It requires energy to get over the Activation energy
  5. DoCt0rPeTe

    DoCt0rPeTe 7+ Year Member

    Jun 17, 2009
    Some terms you should know:
    ExerGonic: - delta G
    Exothermic: - delta H

    This is a crucial concept to understand. ExerGonic means delta G is negative, hence the reaction is spontaneous. I agree in that you may have to add energy to break the bond, but the reaction is often catalzyed by a kinase enzyme.

    Think of the equation for delta G.

    Delta G= delta H -TdeltaS

    deltaH is not the only factor in determining whether a rxn is endergonic or exergonic (+ or - delta G).
    Take a look at the first step of Glycolysis. It's highly unfravorable (+deltaG endergonic etc) to go from a stable glucose, to glucose-6-phosphate, but the hydrolysis of ATP which is a negative delta G will drive the reaction, as the summation of both rxn's delta G's is negative (spontaneous).

    Therefore, coupling a highly exergonic rxn with an endergonic one will drive the endergonic rxn to become spontaneous. This is how many of the rxns in the human body are driven.
  6. drgummybear

    drgummybear 5+ Year Member

    Aug 20, 2010
    ^ great explanation dr. pete!!

    anyway to more specifically answer the OP's question, I think the hydrolysis of ATP is exergonic and exothermic (not endothermic). it does require energy to break the bond, but the energy released from the formation of the much more stable ADP is what makes this reaction exothermic.
  7. ojyarumaru

    ojyarumaru 7+ Year Member

    May 19, 2010
    Thanks a lot everyone, makes more sense to me!
  8. chromosome21

    chromosome21 7+ Year Member

    Sep 6, 2009
    Use reaction coordinate diagram from chemistry kinetics to understand this better. You have to have enough energy to pass by Ea (activation energy). When you want to break bonds, you have to apply energy so that you can easily pass over Ea. Now, when the products are formed, energy will be released, and if the products are more stable than reactants, more energy will be released, which will make the overall reaction exothermic.

    In short, to break ATP bonds, we'll apply energy so that ATP molecules can get over Ea. And Products (ADP + P) are more stable than reactants, thus more energy will be lost at the end when products are formed.

    Attached Files:

    • 1.GIF
      File size:
      2.6 KB
  9. chromosome21

    chromosome21 7+ Year Member

    Sep 6, 2009
    Look at the attachment. Y-axis is energy, x-axis is progress of reaction.
  10. ojyarumaru

    ojyarumaru 7+ Year Member

    May 19, 2010
    Ah, I didn't even think to think of it as a reaction coordinate curve. Thanks for the explanation!

Share This Page