How does the Step I test biochemistry? For example, First Aid has a list of the different lysosomal storage diseases such as Tay-Sachs disease, Fabry's disease, and so forth. For each of these diseases, First Aid lists the deficient enzyme, the product that accumulates as a result of the absence of the enzyme, and clinical manifestations of the disease. For example, in Fabry's disease, the deficient enzyme is alpha-galactosidase, the accumulated product is ceramide trihexoside, and the clinical symptom is renal failure. My question, to those who have taken the Step I is: Do we have to memorize those three components? It appears that we do since all that info comes from the bible, First Aid, but still it seems tedious to do so? I mean, will the step I ask: In Fabry's disease, what is the name of the deficient enzyme?