Here is a definition of Ludwig's Angina "An extensive bilateral phlegmonous cellulitis involving the submental,sublingual, and submandibular spaces. The infection may also progress to involve the lateral pharyngeal and retopharyngeal spaces as well as fascial spaces of the neck and can cause respiatory distress. Trimethoprim-sulfamethoxazole would'nt be my first choice for a pen allergic patient but it could be appropriate if the patient has had problems with other antibiotics!