Quick Q --- Exogenous Steroids + FSH level?

[fuzzywuz]

I wrote a note in my book saying that exogenous steroid use will cause LH to drop (makes sense) and FSH would remain normal. I usually write these notes up after doing Qbank problems. I tried looking for that question (w/ explanation) but can't find it...

I'm having some doubts about whether or not that statement is correct..

Can someone confirm this?

The reason I'm unsure is because I know testosterone sends negative feedback to the hypothalamus AND the pituitary. Since testosterone decreases GnRH, I would assume FSH suffers as well...

Thanks in advance!

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[da8s0859q]

I wrote a note in my book saying that exogenous steroid use will cause LH to drop (makes sense) and FSH would remain normal. I usually write these notes up after doing Qbank problems. I tried looking for that question (w/ explanation) but can't find it...

I'm having some doubts about whether or not that statement is correct..

Can someone confirm this?

The reason I'm unsure is because I know testosterone sends negative feedback to the hypothalamus AND the pituitary. Since testosterone decreases GnRH, I would assume FSH suffers as well...

Thanks in advance!

As in anabolics? I'd say FSH and LH both decrease. This seems to back that up (bottom of p. 627).

 

[MrBigLips]

I have the same note written in my FA from uworld as well and haven't been able to figure it out either.

 

[sgod34]

LH drop with normal FSH is what I would think too.

Mech: exogenous steroids increase testosterone -> neg feedback on LH --> decreased intratesticular testosterone production --> azoospermia and shrunken testicles; since inhibin is unaffected, FSH levels remain normal.

 

[Step1Hash]

LH drop with normal FSH is what I would think too.

Mech: exogenous steroids increase testosterone -> neg feedback on LH --> decreased intratesticular testosterone production --> azoospermia and shrunken testicles; since inhibin is unaffected, FSH levels remain normal.

I think what they were getting at is that testosterone negative feedbacks to both pituitary and hypothalamus. So GnRH should be down too and presumably FSH and LH.

 

[sgod34]

I think what they were getting at is that testosterone negative feedbacks to both pituitary and hypothalamus. So GnRH should be down too and presumably FSH and LH.

Ah, great point! I forgot testosterone can act on FSH and LH. Thanks!

 

[MrBigLips]

I think what they were getting at is that testosterone negative feedbacks to both pituitary and hypothalamus. So GnRH should be down too and presumably FSH and LH.

There it is! Thanks!

 

[Step1Hash]

Ah, great point! I forgot testosterone can act on FSH and LH. Thanks!

There it is! Thanks!

Thanks for the thanks but I just regurgitated what the OP said above lol. We are still confused on if this is actually true or not since uworld says it isn't.

 

[MrBigLips]

... reading fail!

 

[fuzzywuz]

Thanks for the feedback. This is something I'll have to check with the endocrine ppl. Haha