I graduated from Sackler in 2003 - I'll give you all my opinion of the school and my experience there, but if you have specific questions, I'll try to answer them later...
Sackler is an American program based in Tel Aviv - basically it is like any other medical school: first 2 years of basic classroom work with about 1/2 day per week of clinical exposure. The 3rd year is also similar, in which you do the basic clinical rotations in Israeli hospitals. During the 4th year, you spend the first half doing electives anywhere in the US you want and interview for residency. The last half of 4th yar is back in Tel Aviv where you tie up any lose ends and do some electives.
Overall, I have to say that my experience in Israel was amazing! I truly feel that I received an excellent education and was well prepared for residency (with the exception of some small administrative issues that took no longer than 1-2 weeks to figure out). Not only was my education on par (or beyond) my counterparts in the US, but I had a great time during medical school - living in another county teaches you so much more about life and the rest of the world than you'd ever imagine. Additionally, during my 3 1/2 years there, I traveled all around Europe, Jordan, went skiing in France, scuba diving in the sinai, and did a ton of backpacking and camping in Israel.
Now let's face it... there are two purposes to medical school - education and getting into a residency. The education at Sackler is great - teaching is as good as any I've had in the US (and you don't need to know Hebrew for 3rd or 4th years - it helps, but not manditory - I didn't know Hebrew and did fine). Now getting into a residency... I'm not going to lie... that is a little harder. If you do well in med school and on the boards (and you're a normal person), you'll get a good residency. From my class, we had people go to Northwestern, Mount Sinai, NYU, Cornel, Sedar Sinai, Minnesota, and I went to University of Colorado for Internal Medicine. Now, if you want to get into a top ranked residency (ie: Harvard, Stanford, Hopkins), this is probably not the place for you. While you can get into ortho, ophtho, and derm from Sackler (we had a few from my class), it is harder than coming from a US program.
As for me, I did very well on my boards, recently graduated from the University of Colorado Internal Medicine program, am currently working as a hospitalist in Denver, and am applying for a GI fellowship.
I'll quit rambling now... overall, I wouldn't trade my education or experience at Sackler for anything. Going to school in Israel and living in a foreign country isn't for everybody, but it definitly worked for me. If you have any specific questions, I'll try to answer them... good luck!