anyone aware of ongoing research/trials using radiation sensitizers or protectors concurrently with the delivery of SBRT/SRS?
Since both SRS and SBRT give near ablative doses which not only destroy the target but the vasculature as well, there is not a particularly good scientific rationale for radiosensitizers. When your radiation doses alone are not sufficient for LC (locally advanced H&N cancer, cervical cancer, GI cancers) then you toss in chemo for increased cell kill.
Protectants are a bit more interesting. It seems only amifostine has panned out to administer during conventionally fractionated XRT. Since SRS and SBRT has strict size criteria however the chances of side effects (parenchymal necrosis, pneumonitis, RILD) are quite a bit lower.
does anybody still use amifostine? just curious