Originally posted by the boy wonder
Undoubtedly concern over HCV (Hepatitus C) infection is valid as it is a serious disease, and affects almost 4 million americans (more than HIV). However, I don't agree that it is more serious an infection than HIV. To begin with you are incorrect regarding the treatment regime for HCV - interferon therapy is usually used in combination with ribavirin which has almost doubled response rates - indeed the CDC currently quotes 50% response rates, not 10%. The severe responses and side-effects that you quote for interferon therapy are infact identical to the side effects and response rates of patients undergoing standard HIV treatment (AZT, ddI, etc). Your value of 40% resulting in liver cancer also disagrees strongly with CDC values. CDC guidelines currently report 20-30% of people infected with HCV will develop cirrhosis over 10-30 years and of those with cirrhosis, an estimated 25-30% (or up to 5% of all persons initially infected with HCV) will develop end-stage liver disease or liver cancer.
Note that is 5% over 30 odd years. In contrast, while protease inhibitors have extended the period of conversion from HIV infection to full blown AIDS that period still, currently stands at a median value of 7 years. It is also true that in 1980 only 14% of those infected survived more than 1 year after their first AIDS diagnosis and now that figure is 82%. Undoubtedly the face of AIDS has changed, but that still gives 18% of people dying within 7 years of HIV infection. In that time period most people infected with HCV are not even aware of their infection unless they happen to have a liver enzyme test. In contrast even those "doing well" on anti-HIV treatment will have had an average of 4 hospitalizations and had to take drugs every day for 7 years which will have caused varying amounts of fatigue, nausea etc.
If you deal with people that are fine 20 years post HIV infection then you are talking about people that became infected in 1982. These people are exceptionally lucky to still be surviving but are amongst the few that evidently showed good resistance to HIV DESPITE not having drugs (HAART treatment was only introduced in 1996 - so it is impossible that their 20 year survival is entirely attributable to the latest drugs.
While HCV is serious, I think your comparison overly dramatizes the life-impact of this nevertheless (5%) fatal illness and trivializes the impact and death rate of HIV. I do not know where your figures are from. All the figures I have quoted are from the CDC current guidleines on HIV and HCV.