size/charge barrier of GBM

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pizdun

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hi, hopefully im not breaking any rules here but here goes

uworld q[383] states that the endothelium contains the charged anions and is thus the charge barrier
first aid2012 states that the basement membrane is the charge barrier

uworld states that the basement membrane is the size barrier
FA2012 states that the endothelium is the size barrier


anyone can clear this up?

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Fenestrations in the endothelium keep out RBC size and up.

GBM is negatively charged and blocks negatively charged albumin.

Podocyte foot processes create little slit pores that allow glucose, AA, Na, K, phosphate, and other small stuff out.

This is of course for a healthy individual.
 
on a related note, do people have a good way to remember the nephritic vs. nephrotic syndromes? like which disease belongs to which category??
 
Fenestrations in the endothelium keep out RBC size and up.

GBM is negatively charged and blocks negatively charged albumin.

Podocyte foot processes create little slit pores that allow glucose, AA, Na, K, phosphate, and other small stuff out.

This is of course for a healthy individual.

I've also seen in a few practice questions from USMLE Rx that the nephrotic syndrome due to minimal change disease is from loss of the charge-barrier and that due membranous glomerulonephritis is from loss of the size-barrier.
 
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