Sn2

[Hemichordate]

When inversion of stereochemistry occurs with the attack of the nucleophile, is it inversion of the absolute or relative configuration? Does the molecule always change from R to S (or vice versa)?

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[PiBond]

When inversion of stereochemistry occurs with the attack of the nucleophile, is it inversion of the absolute or relative configuration? Does the molecule always change from R to S (or vice versa)?

it's inversion of the absolute configuration of the chiral carbon being attacked. the chiral center is inverted but if there are other chiral centers in the molecule then they'll retain their original configuration (aka they won't be messed with)

 

[Hemichordate]

Ok in that case Examkrackers totally screwed up because it said relative configuration. Don't know why they didn't double check.

 

[Dartmouth2005]

it's inversion of the absolute configuration of the chiral carbon being attacked. the chiral center is inverted but if there are other chiral centers in the molecule then they'll retain their original configuration (aka they won't be messed with)

This guy is right.