Just wondering, because I came across some discussions on patients that were on Cymbalta/Effexor, and due to no efficacy, was decided to be switched to a SSRI. Also pain docs who want to switch a patient off SNRI...
But as we know, at higher doses of Effexor (>100 mg), less serotonin reuptake, and more on the Norepi reuptake.
So if you do a cross-taper, e.g, tapering at 225 mg Effexor, starting 20 mg Prozac, is there a heightened risk of serotonin syndrome? Should you first taper off the SNRI before starting the SSRI, or is that too conservative?
Can you get serotonin syndrome from re-uptaking Serotonin AND norepinephrine, or is it just serotonin (yes, I know, stupid question!)
Thanks,
But as we know, at higher doses of Effexor (>100 mg), less serotonin reuptake, and more on the Norepi reuptake.
So if you do a cross-taper, e.g, tapering at 225 mg Effexor, starting 20 mg Prozac, is there a heightened risk of serotonin syndrome? Should you first taper off the SNRI before starting the SSRI, or is that too conservative?
Can you get serotonin syndrome from re-uptaking Serotonin AND norepinephrine, or is it just serotonin (yes, I know, stupid question!)
Thanks,