Steroids and phospholipase A2

Discussion in 'Step I' started by ChessMaster3000, Jan 14, 2014.

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  1. ChessMaster3000

    ChessMaster3000 5+ Year Member

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    Mar 7, 2010
    I know one of the effects of steroids can be to inhibit phospholipase A2. Is this a more important mechanism than decreasing NFkB?
     
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  3. notbobtrustme

    notbobtrustme Crux Terminatus Banned Account on Hold 2+ Year Member

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    my off the cuff answer with nothing but my own background speaking, is that PLA2 inhibition is more important to immediate inflammation, since those products will attract immune cells, cause vasodilation/constriction and propagate the acute phase of inflammation. NFKB, being a transcription factor, is probably more geared towards mobilizing the inflammation and mounting the correct response.

    Again, this is nothing but my own dingus talking here.
     
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