Dismiss Notice
Hey Texans—join us for a DFW meetup! Click here to learn more.

Stuck on One Question NBME Form 1

Discussion in 'Step I' started by Jack P, Jul 24, 2006.

  1. Jack P

    Jack P Member
    2+ Year Member

    Joined:
    Jul 19, 2006
    Messages:
    49
    Likes Received:
    1
    Status:
    Medical Student
    Hi all, I'm new to this forum and in the middle of study for Step 1. Took the form 1 on friday and am going over my answers...I found a bit of a contradiction in a question regarding hereditary angioedema.

    The question (paraphrased to protect copyright ;) ): Young girl with an acute onset of facial swelling and dyspnea. Hereditary Angioedema is suspected (C1 esterase inhibitor), what will be found in serum?
    1. Decreased serum C4
    2. Increased serum properdin
    3. Normal C1q
    4. Normal C1s
    5. Normal C2

    In a bit of research I found out that:
    So here...answers 1 and 3 could be true? I could be totally off but does anyone have an answer?
     
  2. Note: SDN Members do not see this ad.

  3. trudub

    trudub Senior Member
    7+ Year Member

    Joined:
    Oct 23, 2003
    Messages:
    337
    Likes Received:
    2
    From a basic science standpoint, I would assume the answer is low C4. That makes sense since the C' pathway is uninhibited it uses up the C4. That would also make the C1q levels high. So, without any outside knowledge that is what I assume the answer is. Maybe for some reason the C1q levels are actually normal but the C4 levels should definitely be low.
     
  4. Jack P

    Jack P Member
    2+ Year Member

    Joined:
    Jul 19, 2006
    Messages:
    49
    Likes Received:
    1
    Status:
    Medical Student
    Definitely agree on the low C4...just got confused on the normal C1q since I've found examples in the literature that it can be the case. But I guess you have to ask...what is the most common finding? I found the "lab studies" from emedicine which is usually quite a good resource...better than wikipedia anyway!
     

Share This Page