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- Nov 26, 2013
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So I get that thiamine (B1) is needed for several metabolic pathways such as TCA cycle, HMP shunt, and for branched-chain amino acid dehydrogenase as well.
So in general, many of the symptoms you would see would be muscle weakness such as ophthalmoplegia, which I am assuming can happen b/c of the lack of ATP production. But why eye muscles among many other muscles?
Also, how do you explain ataxia, memory loss, and cerebral hemorrhage?
Also FA says Wernicke-Korsakoff can lead to damage to medial dorsal nucleus of thalamus and mammilary bodies, I just feel like these are kind of random symptoms that are perhaps irrelevant to metabolic pathways affected by thiamine deficiency.
One explanation I can think of perhaps is the lack of NADPH production since thiamine is needed for transketolase in the PPP (Pentose Phosphate Pathway), but there are many organs that require appropriate NADPH to maintain redox balance, so why damage in medial dorsal nucleus of thalamus and mammilary bodies?
Can anyone enlighten me? Many thanks in advance.
So in general, many of the symptoms you would see would be muscle weakness such as ophthalmoplegia, which I am assuming can happen b/c of the lack of ATP production. But why eye muscles among many other muscles?
Also, how do you explain ataxia, memory loss, and cerebral hemorrhage?
Also FA says Wernicke-Korsakoff can lead to damage to medial dorsal nucleus of thalamus and mammilary bodies, I just feel like these are kind of random symptoms that are perhaps irrelevant to metabolic pathways affected by thiamine deficiency.
One explanation I can think of perhaps is the lack of NADPH production since thiamine is needed for transketolase in the PPP (Pentose Phosphate Pathway), but there are many organs that require appropriate NADPH to maintain redox balance, so why damage in medial dorsal nucleus of thalamus and mammilary bodies?
Can anyone enlighten me? Many thanks in advance.