You can tailor your application to a TYPE of school -- ex. Research focused, Primary care driven, Rural or underserved mission, Historically Black, Spanish-speaking. But yeah, it would almost certainly be a mistake to tailor too much for one school. That's what secondaries are for.
@5Swords - are you a Texas resident? If so, it's probably not necessary since the TX schools (due probably to their notorious IS bias) don't receive such an overwhelming # of applications that yours won't actually get read. And if you're NOT IS, it'll take a helluva lot more than networking to get you noticed -- like a 95%ile MCAT.