Jul 13, 2016
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Medical Student
why is the Choriocarcinoma associated with bilateral/multiple theca lutein cysts?
Its because of the high levels of beta hCG secreted by the tumor in choriocarcinoma. The theca interna of ovarian follicles is normally stimulated by LH.
hCG and LH have a common alpha sub-unit, so hCG can actually stimulate LH receptors on theca interna cells to a certain extent. The over-stimulation of LH receptors by Beta-hCG causes the formation of multiple, bilateral theca lutein cysts in the ovaries.