Okay, unlike a lot of posters on this thread, I don't know anything about your stats, your home state, etc., so my advice is fairly general. I think the key is to pick a wide range of schools, rather than trying to apply mostly to your "dream" schools and several safety schools. The problem with perceived "safety" schools, is that a lot of applicants perceive them this way, and thus they get inundated with applications (when I applied, in 2000-2001, the "safety schools" tended to get on the order of 8000-10,000 applications vs. more selective schools which had 3000-4000 applicants). Thus, the sheer number of people applying can diminish your chances of even getting an interview.
So my general advice would be to apply to 15-20 schools total. I would not really go above 25 -- if you are honest with yourself when assessing your application, anything above 20 may be overkill, not to mention it takes up a lot of time and money). Apply to 4-6 "dream" schools, 4-6 schools that seem realistic for you based on your numbers, and 4-6 schools that may have average stats below yours. Your state school or schools are always ones that you should consider for one of these pools (and yes, I'm saying this as a CA resident). ABOVE ALL, PLEASE make sure that these are all schools that you would seriously consider attending. Your opinion may change after interviewing, but don't bother applying to Pitt if you really can't fathom the idea of living in Pittsburgh for 4 years. It's a waste of your time and the school's time for you to apply somewhere you don't think you'd actually attend. Even if you think you are a stellar applicant, strange things can happen, and you may only get in to one of the schools that you applied to.
So, to finally answer your question as to "safety" schools, your state school may fall into this category; if you have extremely high stats and a generally competitive application, schools such as USC, Med. College of Wisconsin, SLU, Tulane, NYMC, Med. College of Virginia, Finch, all generally fall into the "safer" category. Be wary of most state schools with their strong preferences for in-state residents.
Good luck.