At my job I've inherited some of the more complex cases after someone in my hospital system left. It is a population of veterans who get intensive case management and a number of them are diagnosed with treatment resistant schizophrenia/bipolar disorder. Classically, I was taught that if someone fails two antipsychotic trials, it is not unreasonable to consider clozapine and there is not much evidence for multiple antipsychotics. However, a number of my new vets are on 2 antipsychotics and possibly up to a couple of mood stabilizers. Does anyone have any recommended reading on this or are familiar with antipsychotic combinations? I hear abilify with seroquel just makes no sense, and fortunately I have not seen anyone on that combination. But I'm more used to treating bread and butter depression and anxiety. It's been awhile since I managed these types of cases. I'll be doing some reading of my own but was wondering what other's people's experiences were. Thanks!