I live in Kansas City and have had two kids born at KU, so I am somewhat qualified to answer this question for you. The area directly surrounding KU Med Center, i.e. five to ten blocks, is pretty rough. But there are $500k houses within 5 minutes of KU, so it's not like some huge ghetto. Kansas City is not a HUGE city, so it takes about 30 mins to get from one side to the other. You can live on the Kansas side of the state line, but you will pay more for rent/housing and the taxes and cost of living will kill you. You can live on the Missouri side for much less, and be within 20 mins of the hospital easily. I used to live in some loft apartments in the downtown area on the Missouri River in the "River Market area-- an outdoor farmer's market with lots of things do do: great bbq, jazz clubs, live music, outdoor festivals, etc. I think that is a great place for a single person, or a married couple without kids to live, and it is within 10 mins of KU Med Center.