Urinary Chloride & metabolic alkalosis

[codebluewinniethepooh]

Hello everyone,

My question is why the metabolic alkalosis in Barter syndrome and Gitelman syndrome is saline unresponsive, while it is saline responsive in patients with current diuretics use? this is confusing to me because the pathophysiology of these two syndromes mimic loop diuretics and thiazide diuretics, respectively.

Your feedback is appreciated

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