VIPoma and hypochlorhydria

[cheruka]

Why does VIPoma cause hypochlorhydria? Does VIP influence intrinsic factor or B12 absorption? Or is it because VIPoma causes diarrhea which could cause IF/B12 deficiencies which in turn lead to hypochlorhydria?

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[cheruka]

Or could it be that VIP can suppress Gastrin?

 

[ASAPRocky]

jigga, you ask too much hardcore physiology. I'm a big fan that you need to know pathophysiology to understand things, but this stuff is too much. Jigga please.

 

[Transposony]

http://emedicine.medscape.com/article/125910-overview

VIP resembles secretin, which stimulates the secretion of alkaline pancreatic juices. In the stomach, VIP inhibits histamine- and pentagastrin-stimulated acid secretion.

 

[gravitywave]

there is no way this kind of stuff is worth knowing for 2ck. just no way.

 

[Brucelaa67]

Any link between B12 deficiency and acid secretion?