Hey Baylor21:
Definitely apply to Wash U.! I am a bit biased in my enthusiasm, as I am about begin medical school there (as part of the MSTP), but I do believe that Wash U. has one of the strongest MD/PhD programs in the country.
Certainly the medical school and research are very strong, competitive with other top academic centers without a doubt. Wash U.'s MSTP is one of the largest programs, with about 22-25 students in a medical school class of 120, making the MSTPs very well-represneted. Moreover, Wash U.'s MSTP is EXTREMELY well-organized. If you interview there, you will see what I mean--the administrators are wonderful, the MSTP committee and other advisors constantly provide support and encouragement, advise students, etc. etc. That would explain why the students there are so satisfied... (that, and the P/F of the first year, low living expense, etc.)
All these things things really sold me on the school earlier this year. Even though unlike you, I never would have imagined myself living in the Midwest, I fell in love with the friendy and laid-back atmosphere at Wash U. After interviewing at a dozen places (a lot of money...), I knew that Wash U. was the perfect place for me.
So I'd definitely encourage you to apply, baylor. In terms of acceptance, yes, the school looks heavily on grades and MCAT (they are proud of their #1 in student selectivity ranking), but if you make it to the interview your chances are VERY high. That's because Wash U.'s MSTP accepts all students right after the interview, so you are not really competing with anybody else. If they like you, you're in, regardless of the other applicants. I think the interview there also focuses VERY much on research, in my opinion more so than other places, so if you've got a thorough understanding of your research and your dedication to pursue it, then you'll do well. (FYI: 50-60 out of 90 interviewees are accepted each year.)
Good luck! And if there are any other incoming Wash U. students, I would love to speak to them!