I'm not entirely qualified to answer, having never been in a college environment and all, but I can speak based off of what I've seen on this forum so far. I've perused several threads bearing resemblance to the you've posted here, and one thing I've noticed is that a ton of members currently enrolled in medical school suggest taking the route that would leave you with the most competitive GPA. According to pre-med and med students alike; GPA (as well as E.C.'s and the MCAT) plays a huge role throughout the application process. Personally, I feel that you should choose whichever University suits your educational and lifestyle needs best. If you personally believe that the rigor and prestige of WashU will help you in the long run despite the probable grade deflation and competition, go for it. I've heard nothing but good things about WashU from it's current and past students. If you'd rather attend a school that you would undoubtedly perform well in without the rigor and prestige of WashU, why not. Having an easier pre-med experience at Tufts might enable you to develop a better social life than you would have had at WashU. I've also heard that your choice of undergraduate education does not play a huge role relative to the importance of GPA and standardized test scores. While attending WashU might catch an admissions officer's eye (really have no concept of Med School admissions, so don't take my word on this) due to its notoriety as a rough n' tough college, it's likely that they'll prioritize your performance. Don't discount Tufts as an easier school in comparison to WashU, though. Even if it's considered to be easier than WashU, it's still entirely possible that the course load there will be rigorous as well! Also make sure to research the courses and such to make sure you're getting the best educational medium for you. If I had to personally choose between either school, I'd likely go with WashU. I love their curriculum and campus! Again, I'm only in High School, so my opinion is really not representative of one that somebody with experience might give. I'd love to hear about whichever you decide to attend; hearing about other people's college experiences is great. I wish you luck on your future endeavors. I hope this helped to some degree. (I apologize in advance for any grammatical errors that this post is likely riddled with, I had to type this response up in the last few seconds of my second period. :^))