For licensing, only that the GPA will let you leave with a degree. For fellowship or residency applications, I never look at GPA besides making sure they didn't repeat a year (and Niosh uses the same scale that is used for screening normally which you get credit for decent grades but it is only one consideration among several). There's some leeway though if we happen to know the school (Rutgers, UConn, University of Florida, MUSC, Iowa) tend to have lower GPA's (average about .2-.4 less) than their peers but are well known to have more punitive faculty about grading. I wouldn't suggest you do the "2.2 will get me through" but you don't have to be Dr. 4.0 either. For hiring actual pharmacists though, I never look at the GPA ever (don't even care at that point if they repeated a year), and don't even look at the OPM evaluations unless the candidate did not graduate in either the US or Canada. Possession of an unrestricted license and really how well you interview in comparison with what you put down in your CV is kind of a thing.
(One other thing, if I see an MS or PhD graduate degree with a 4.0 apply in a technical field for some of the jobs I currently oversee, I almost always scrutinize their transcripts. I usually will reject them for reasons that they did not push themselves as hard as they should have if they did completely perfectly at their graduate work for the GPA. A 4.0 GPA at the graduate level is viewed as highly negative in the 2nd year for the inability to choose the appropriate level of difficulty in their studies as they probably didn't select the terminal classes in their series and did not spend enough time on what they should have been doing in terms of publishing.)